Work in the laboratory of the scientific founders of 4E Therapeutics demonstrates that these immune-derived factors change gene expression at the level of translation.
Our Unique Approach to Treating Neuropathic Pain
Changes in gene expression are required for neuronal plasticity that drives chronic pain. Immune cells respond to injury through the release of cytokines, chemokines and growth factors that then induce pathological neuronal plasticity in the excitability of nociceptors, the primary pain-sensing neurons innervating the entire body.
Our Science
MNK-mediated phosphorylation of eIF4E causes increased gene expression that amplifies the generation of pain signals.
4E Therapeutics MNK inhibitors shut off the peripheral generator of pain signals, blocking the flow to the brain where pain perception occurs.
